Review of Advances in Coating and Functionalization of Gold Nanoparticles: From Theory to Biomedical Application
Nanoparticles, especially gold nanoparticles (Au NPs) have gained increasing interest in biomedical applications. Used for disease prevention, diagnosis and therapies, its significant advantages in therapeutic efficacy and safety have been the main target of interest. Its application in immune system prevention, stability in physiological environments and cell membranes, low toxicity and optimal bioperformances are critical to the success of engineered nanomaterials. Its unique optical properties are great attractors. Recently, several physical and chemical methods for coating these NPs have been widely used. Biomolecules such as DNA, RNA, peptides, antibodies, proteins, carbohydrates and biopolymers, among others, have been widely used in coatings of Au NPs for various biomedical applications, thus increasing their biocompatibility while maintaining their biological functions. This review mainly presents a general and representative view of the different types of coatings and Au NP functionalization using various biomolecules, strategies and functionalization mechanisms.
Citação
@online{rosero,_wilmmer_alexander2024,
author = {Rosero, Wilmmer Alexander, Arcos and Barbezan, Angelica,
Bueno and De Souza, Carla, Daruich and Martins Rostelato, Maria
Elisa, Chuery},
title = {Review of Advances in Coating and Functionalization of Gold
Nanoparticles: From Theory to Biomedical Application},
volume = {16},
number = {2},
date = {2024-02-09},
doi = {10.3390/pharmaceutics16020255},
langid = {pt-BR},
abstract = {Nanoparticles, especially gold nanoparticles (Au NPs) have
gained increasing interest in biomedical applications. Used for
disease prevention, diagnosis and therapies, its significant
advantages in therapeutic efficacy and safety have been the main
target of interest. Its application in immune system prevention,
stability in physiological environments and cell membranes, low
toxicity and optimal bioperformances are critical to the success of
engineered nanomaterials. Its unique optical properties are great
attractors. Recently, several physical and chemical methods for
coating these NPs have been widely used. Biomolecules such as DNA,
RNA, peptides, antibodies, proteins, carbohydrates and biopolymers,
among others, have been widely used in coatings of Au NPs for
various biomedical applications, thus increasing their
biocompatibility while maintaining their biological functions. This
review mainly presents a general and representative view of the
different types of coatings and Au NP functionalization using
various biomolecules, strategies and functionalization mechanisms.}
}