Solvent-dependent formation kinetics of L,L-diphenylalanine micro/nanotubes
Investigating the molecular mechanism underlying the aggregation process of amyloid fibers is of great importance both for their implications in several degenerative diseases and for the design of new materials based on self-assembly. , Investigating the molecular mechanism underlying the aggregation process of amyloid fibers is of great importance both for its implications in several degenerative diseases and for the design of new materials based on self-assembly. In particular, micro/nanotubes of L,L-diphenylalanine have been investigated as a model of amyloid plaques in Alzheimer’s disease and also for their broad range of physical properties, e.g. , good thermo- and mechanical stability, semiconductivity, piezoelectricity and optical properties. It has been reported that the assembly/disassembly dynamics of L,L-diphenylalanine crystals is influenced by the solvent composition being triggered by evaporation of solvents. In fact the solvatomorphism of this peptide-based nanomaterial is complex and rich attracting great attention. Here we investigated the growing kinetics of the micro/nanotubes of L,L-diphenylalanine in samples prepared with toluene, ethanol, and acetic acid solvents by time-resolved Raman spectroscopy. Our results indicated that the self-assembly in this case competes with the water evaporation process contrary to what is reported by samples prepared with widely used solvent 1,1,1,3,3,3-hexafluoro-2-propanol. We note that exclusively tubular structures (being hollow for the toluene solvent case) were observed. Interestingly our results support the fact that for acetic acid, ethanol, and toluene the micro/nanotube formation process is autocatalytic instead of being nucleation-dominating as reported for samples prepared using solvent 1,1,1,3,3,3-hexafluoro-2-propanol.
Citação
@online{carla_carolina_silva2023,
author = {Carla Carolina Silva , Bandeira and Letícia Marques Caviola
, Foiani and Giovana Bonano , Carlos and Mariana Sayuri , Ishikawa
and Paula Maria Gabriela Leal , Ferreira and Silva Martinho,
Herculano, Da},
title = {Solvent-dependent formation kinetics of L,L-diphenylalanine
micro/nanotubes},
volume = {25},
number = {6},
date = {2023-01-01},
doi = {10.1039/D2CP03491C},
langid = {pt-BR},
abstract = {Investigating the molecular mechanism underlying the
aggregation process of amyloid fibers is of great importance both
for their implications in several degenerative diseases and for the
design of new materials based on self-assembly. , Investigating the
molecular mechanism underlying the aggregation process of amyloid
fibers is of great importance both for its implications in several
degenerative diseases and for the design of new materials based on
self-assembly. In particular, micro/nanotubes of L,L-diphenylalanine
have been investigated as a model of amyloid plaques in Alzheimer’s
disease and also for their broad range of physical properties, e.g.
, good thermo- and mechanical stability, semiconductivity,
piezoelectricity and optical properties. It has been reported that
the assembly/disassembly dynamics of L,L-diphenylalanine crystals is
influenced by the solvent composition being triggered by evaporation
of solvents. In fact the solvatomorphism of this peptide-based
nanomaterial is complex and rich attracting great attention. Here we
investigated the growing kinetics of the micro/nanotubes of
L,L-diphenylalanine in samples prepared with toluene, ethanol, and
acetic acid solvents by time-resolved Raman spectroscopy. Our
results indicated that the self-assembly in this case competes with
the water evaporation process contrary to what is reported by
samples prepared with widely used solvent
1,1,1,3,3,3-hexafluoro-2-propanol. We note that exclusively tubular
structures (being hollow for the toluene solvent case) were
observed. Interestingly our results support the fact that for acetic
acid, ethanol, and toluene the micro/nanotube formation process is
autocatalytic instead of being nucleation-dominating as reported for
samples prepared using solvent 1,1,1,3,3,3-hexafluoro-2-propanol.}
}