Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis
Background: This study is a systematic review with meta-analysis comparing radioactive seed localization (RSL) versus radio-guided occult lesion localization (ROLL) and wire-guided localization (WGL) for patients with impalpable breast cancer undergoing breast-conserving surgery and evaluating efficacy, safety, and logistical outcomes. The protocol is registered in PROSPERO with the number CRD42022299726. Methods: A search was conducted in the Embase, Lilacs, Pubmed, Scielo, Web of Science, and clinicaltrials.gov databases, in addition to a manual search in the reference list of relevant articles, for randomized clinical trials and cohort studies. Studies selected were submitted to their own data extraction forms and risk of bias analysis according to the ROB 2 and ROBINS 1 tools. A meta-analysis was performed, considering the random effect model, calculating the relative risk or the mean difference for dichotomous or continuous data, respectively. The quality of the evidence generated was analyzed by outcome according to the GRADE tool. Overall, 46 articles met the inclusion criteria and were included in this systematic review; of these, 4 studies compared RSL and ROLL with a population of 1550 women, and 43 compared RSL and WGL with a population of 19,820 women. Results: The results showed that RSL is a superior method to WGL in terms of surgical efficiency in the impalpable breast lesions’ intraoperative localization, and it is at least equivalent to ROLL. Regarding security, RSL obtained results equivalent to the already established technique, the WGL. In addition to presenting promising results, RSL has been proven to be superior to WGL and ROLL technologies.
Citação
@online{hortência_h._j.2024,
author = {Hortência H. J. , Ferreira and Souza, Carla Daruich, De and
Lorena , Pozzo and Martha S. , Ribeiro and Maria Elisa C. M. ,
Rostelato},
title = {Radioactive Seed Localization for Nonpalpable Breast Lesions:
Systematic Review and Meta-Analysis},
volume = {14},
number = {4},
date = {2024-02-17},
doi = {10.3390/diagnostics14040441},
langid = {pt-BR},
abstract = {Background: This study is a systematic review with
meta-analysis comparing radioactive seed localization (RSL) versus
radio-guided occult lesion localization (ROLL) and wire-guided
localization (WGL) for patients with impalpable breast cancer
undergoing breast-conserving surgery and evaluating efficacy,
safety, and logistical outcomes. The protocol is registered in
PROSPERO with the number CRD42022299726. Methods: A search was
conducted in the Embase, Lilacs, Pubmed, Scielo, Web of Science, and
clinicaltrials.gov databases, in addition to a manual search in the
reference list of relevant articles, for randomized clinical trials
and cohort studies. Studies selected were submitted to their own
data extraction forms and risk of bias analysis according to the ROB
2 and ROBINS 1 tools. A meta-analysis was performed, considering the
random effect model, calculating the relative risk or the mean
difference for dichotomous or continuous data, respectively. The
quality of the evidence generated was analyzed by outcome according
to the GRADE tool. Overall, 46 articles met the inclusion criteria
and were included in this systematic review; of these, 4 studies
compared RSL and ROLL with a population of 1550 women, and 43
compared RSL and WGL with a population of 19,820 women. Results: The
results showed that RSL is a superior method to WGL in terms of
surgical efficiency in the impalpable breast lesions’ intraoperative
localization, and it is at least equivalent to ROLL. Regarding
security, RSL obtained results equivalent to the already established
technique, the WGL. In addition to presenting promising results, RSL
has been proven to be superior to WGL and ROLL technologies.}
}